This study showed while both zoledronic acid and alendronate improved lumbar spine BMD, there was no statistically significant difference between them. The most common reasons for prescribing zoledronic acid were oral bisphosphonate intolerance and fragility fractures/decreased BMD despite alendronate use. However this was not statistically significant (odds ratio 0.5, 95% confidence interval 0.2 to 1.5, P=0.2). 8 patients (23%) suffered fragility fractures post zoledronic acid compared to 11 (37%) post alendronate. However, this did not reach statistical significance ( P=0.37). The median percentage improvement in total hip BMD with zoledronic acid was 0.3% (IQR −2.3 to 6.4%) and with alendronate was 0.8% (IQR −2.7 to 3.4%). Whilst there was a trend towards greater improvement with alendronate compared to zoledronic acid, this was not statistically significant ( P=0.43). The median percentage improvement in lumbar spine BMD with zoledronic acid was 5.5% (Interquartile range (IQR) −0.2 to 9.1%) and with alendronate was 6.45% (IQR 1.8 to 10.4%). The number of fragility fractures post-bisphosphonate was recorded as was the reason for choosing zoledronic acid over alendronate. Data were analysed using Mann-Whitney-tests in Minitab 15 statistical software.
35 patients received annual 5 mg IV zoledronic acid infusions over 3 years 30 patients received 70 mg once weekly oral alendronate over mean duration of 3 years. BMD at the lumbar spine and total hip pre- and post-bisphosphonate were recorded for 65 patients with osteoporosis ( T score ≤−2.5) from retrospective analysis of DEXA scans. This study compared changes in BMD in patients with osteoporosis treated with zoledronic acid vs alendronate. First, you’ll need to complete a quick form to help us authenticate that you are a student.
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Repeating the step for another column, will then show the basic stats, including the mean, for that column as well.Zoledronic acid has been shown to reduce the risk of fractures and improve bone mineral density (BMD) in osteoporosis vs placebo. Welcome to the Minitab Download Site If you are enrolled in a course and received a valid coupon code with your course materials, you can use that code to download your own personal copy of Minitab at no cost.
If you already have data in Minitab, or you have multiple variables for which you want to calculate the mean, you can simply double click the correct column in step 2 above. Notice that you also get several other values, such as the number of data values (N), the standard deviation (StDEV), as well as the first and third quartiles (Q1 and Q3). In the figure below, the mean is in the red box. Here, double click C1 and then click OK.Īfter you click OK, the following will display in the part of the screen above your data. Once you click this, a new menu will come up. Step 2: Click Stat and select Basic Statistics, then Display Descriptive Statistics… To do this, highlight the space right below C1 and type in a name. While not required, you should also be sure to label the column/data. Instead, enter it only in the white portion of the spreadsheet. Do not enter data in the grayed out space right below C1. We will use the following data set as an example: 16, 14, 15, 17, 16, 16, 18. There is no rule that says you have to use the first column, but if you have only one list of data, go ahead and type it into the column C1.